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Once you have created a large EndNote library you can save a compressed  copy of your original library and any associated files ( such as PDFs) to another location as a backup file

You can also use this method to transfer your library and associated files to another computer

Open your EndNote library

• Click

• File | Compressed Library (.enlx)

• Choose appropriate options for your compressed library and click Next
• Save the compressed library where you wish to store your back up file - USB stick, portable hard drive, another computer...
• To uncompress the .enlx version of your EndNote library double click on it or in EndNote use File | Open